Publications

 

2018

Mathews DV, Dong Y, Higginbotham LB, Kim SC, Breeden CP, Stobert EA, Jenkins J, Tso JY, Larsen CP, Adams AB. CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection. J Clinical Invest. 2018 Oct 1;128(10):4557-4572. Pubmed [journal] PMID: 30222140

Dana Tedesco, Manoj Thapa, Chui-Yoke Chin, Yong Ge, Minghao Gong, Jing Li, Sanjeev Gumber, Patrick Speck, Elizabeth J. Elrod, Eileen M. Burd, William H. Kitchens, Joseph F. Magliocca, Andrew B. Adams, David S. Weiss, Mansour Mohamadzadeh, Arash Grakou. Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-cell Receptor-positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology. 2018 Feb 15. pii: S0016-5085(18)30214-2. doi: 10.1053/j.gastro.2018.02.019. Pubmed [journal] PMID: 29454797

Newell KA, Adams AB, Turka LA.Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients. Hum Immunol. 2018 Feb 12. pii: S0198-8859(18)30045-4. doi:10.1016/j.humimm.2018.02.007. Review. PMID: 29448053

2017

Kim SC, Wakwe W, Higginbotham LB, Mathews DV, Breeden CP, Stephenson AC, Jenkins J, Strobert E, Price K, Price L, Kuhn R, Wang H, Yamniuk A, Suchard S, Farris AB 3rd, Pearson TC, Larsen CP, Ford ML, Suri A, Nadler S, Adams AB. Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection. Am J Transplant. 2017 May;17(5):1182-1192. Pubmed [journal] PMID: 28097811

Newman KL, Lynch RJ, Adams AB, Zhang R, Pastan SO, Patzer RE. Hospitalization Among Individuals Waitlisted for Kidney Transplant. Transplantation. 2017 Jun 6. Pubmed [journal] PMID: 28590946

Adams AB, Goldstein J, Garrett C, Zhang R, Patzer RE, Newell KA, Turgeon NA, Chami AS, Guasch A, Kirk AD, Pastan SO, Pearson TC, Larsen CP. Belatacept Combined with Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function. Am J Transplant. 2017 May 23. Pubmed [journal] PMID: 28544101

Mathews DV, Wakwe WC, Kim SC, Lowe MC, Breeden C, Roberts ME, Farris AB, Strobert EA, Jenkins JB, Larsen CP, Ford ML, Townsend R, Adams AB. Belatacept Resistant Rejection is Associated with CD28+ Memory CD8 T cells. Am J Transplant. 2017 May 14. Pubmed [journal] PMID: 28502128

Cortes-Cerisuelo M, Laurie SJ, Mathews DV, Winterberg PD, Larsen CP, Adams AB, Ford ML. Increased Pre-Transplant Frequency of CD28+ CD4+ TEM Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients. Am J Transplant. 2017 May 14. Pubmed [journal] PMID: 28502091

Kitchens WH, Dong Y, Mathews DV, Breeden CP, Strobert E, Fuentes ME, Larsen CP, Ford ML, Adams AB. Interruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection. JCI Insight. 2017 Mar 9;2 Pubmed [journal] PMID: 28289708

Kim SC, Wang J, Dong Y, Mathews DV, Albrecht JA, Breeden CP, Farris AB, Lukacher AE, Ford ML, Newell KA, Adams AB. Alloimmunity But Not Viral Immunity Promotes Allograft Loss in a Mouse Model of Polyomavirus-Associated Allograft Injury. Transplant Direct. 2017 May 12. Pubmed [journal] PMID: 28620645

2016

Lynch RJ, Zhang R, Patzer RE, Larsen CP, Adams AB. Waitlist Hospital Admissions Predict Resource Utilization and Survival After Renal Transplantation. Annals of surgery. 2016; 264(6):1168-1173. PubMed [journal] PMID: 26720436

Tedesco D, Thapa M, Gumber S, Elrod EJ, Rahman K, Ibegbu CC, Magliocca JF, Adams AB, Anania F, Grakoui A. CD4+ Foxp3+ T cells promote aberrant IgG production and  maintain CD8+ T cell suppression during chronic liver disease. Hepatology (Baltimore, Md.). 2016; PubMed [journal] PMID: 27774611

Lynch RJ, Zhang R, Patzer RE, Larsen CP, Adams AB. First-Year Waitlist Hospitalization and Subsequent Waitlist and Transplant Outcome. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016; PubMed [journal] PMID:27664797

Adams AB, Ford ML, Larsen CP. Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(6):2045-50. PubMed [journal] PMID: 27591335

Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS. The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016; PubMed [journal] PMID: 27500470

Adams AB, Newell KA. Transplantation tolerance: Coming of age. Hepatology (Baltimore, Md.). 2016; 64(2):347-9. PubMed [journal] PMID: 26991323

Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ. Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology. American
journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016;16(6):1726-38. NIHMSID: NIHMS746514 PubMed [journal] PMID: 26705099, PMCID: PMC4874845

Newman KL, Fedewa SA, Jacobson MH, Adams AB, Zhang R, Pastan SO, Patzer RE. Racial/Ethnic Differences in the Association Between Hospitalization and Kidney Transplantation Among Waitlisted End-Stage Renal Disease Patients.Transplantation. 2016; NIHMSID: NIHMS741032 PubMed [journal] PMID: 26845307, PMCID: PMC4972697

Kitchens WH, Adams AB. Nonhuman primate models of transplant tolerance: closer to the holy grail. Current opinion in organ transplantation. 2016; 21(1):59-65. PubMed [journal] PMID: 26709576

2015

Higginbotham L, Ford ML, Newell KA, Adams AB. Preventing T cell rejection of pig  xenografts. International journal of surgery (London, England). 2015; 23(Pt B):285-90. PubMed [journal] PMID: 26306770

Estrada JL, Martens G, Li P, Adams A, Newell KA, Ford ML, Butler JR, Sidner R, Tector M, Tector J. Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes. Xenotransplantation. 2015; 22(3):194-202. NIHMSID: NIHMS665047 PubMed [journal] PMID: 25728481, PMCID: PMC4464961

Higginbotham L, Mathews D, Breeden CA, Song M, Farris AB 3rd, Larsen CP, Ford ML, Lutz AJ, Tector M, Newell KA, Tector AJ, Adams AB. Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model. Xenotransplantation. 2015; 22(3):221-30. NIHMSID: NIHMS797220 PubMed [journal] PMID: 25847130, PMCID: PMC4930152

Velazquez VM, Uebelhoer LS, Thapa M, Ibegbu CC, Courtney C, Bosinger SE, Magliocca JF, Adams AB, Kirk AD, Knechtle SJ, Kalman D, Suthar MS, Grakoui A.Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development. Hepatology (Baltimore, Md.). 2015;61(3):843-56. NIHMSID: NIHMS638180 PubMed [journal] PMID: 25331524, PMCID: PMC4340762

2014

Knechtle SJ, Adams AB. Belatacept: is there BENEFIT for liver transplantation too? American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2014;14(8):1717-8. PubMed [journal] PMID: 25041120

Squires MH 3rd, Hanish SI, Fisher SB, Garrett C, Kooby DA, Sarmiento JM, Cardona K, Adams AB, Russell MC, Magliocca JF, Knechtle SJ, Staley CA 3rd, Maithel SK.Transplant versus resection for the management of hepatocellular carcinoma meeting Milan Criteria in the MELD exception era at a single institution in a UNOS region with short wait times. Journal of surgical oncology. 2014; 109(6):533-41. NIHMSID: NIHMS657601 PubMed [journal] PMID: 24347475, PMCID: PMC4321953

Sullivan JA, Adams AB, Burlingham WJ. The emerging role of TH17 cells in organ transplantation. Transplantation. 2014; 97(5):483-9. PubMed [journal] PMID: 24212502

Ford ML, Adams AB, Pearson TC. Targeting co-stimulatory pathways: transplantation and autoimmunity. Nature reviews. Nephrology. 2014; 10(1):14-24. NIHMSID: NIHMS574732 PubMed [journal] PMID: 24100403, PMCID: PMC4365450

2012 & Earlier

Lowe M, Badell IR, Thompson P, Martin B, Leopardi F, Strobert E, Price AA, Abdulkerim HS, Wang R, Iwakoshi NN, Adams AB, Kirk AD, Larsen CP, Reimann KA. A novel monoclonal antibody to CD40 prolongs islet allograft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012; 12(8):2079-87. NIHMSID: NIHMS362878 PubMed [journal] PMID: 22845909, PMCID: PMC3410651

Adams AB, Newell KA. B cells in clinical transplantation tolerance. Seminars in immunology. 2012; 24(2):92-5. PubMed [journal] PMID: 21958959

Kitchens WH, Adams AB, Hughes CB, Subramanian RM. Diagnostic challenges in the evaluation of hepatic grafts from donors with HELLP syndrome: case report and review of the literature. Transplantation proceedings. 2011; 43(10):4010-2. PubMed [journal] PMID: 22172890

Turgeon NA, Avila JG, Cano JA, Hutchinson JJ, Badell IR, Page AJ, Adams AB, Sears MH, Bowen PH, Kirk AD, Pearson TC, Larsen CP. Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2010; 10(9):2082-91. NIHMSID: NIHMS337220 PubMed [journal] PMID: 20883542, PMCID: PMC3335736

Conrad MF, Adams AB, Guest JM, Paruchuri V, Brewster DC, LaMuraglia GM, Cambria RP. Secondary intervention after endovascular abdominal aortic aneurysm repair. Annals of surgery. 2009; 250(3):383-9. PubMed [journal] PMID: 19652592

Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007; 7(2):320-35. PubMed [journal] PMID: 17241112

31.   Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD. A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2006; 6(5 Pt 1):876-83. PubMed [journal] PMID: 16611323

32.   Emmanouilidis N, Guo Z, Dong Y, Newton-West M, Adams AB, Lee ED, Wang J, Pearson  TC, Larsen CP, Newell KA. Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells. Transplantation. 2006; 81(3):455-62. PubMed [journal] PMID: 16477234

33.   Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP. NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation. American journal of transplantation : official journal of the American Society of Transplantation  and the American Society of Transplant Surgeons. 2006; 6(2):292-304. PubMed [journal] PMID: 16426313

34.   Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobert E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Turk LA, Bajorath J, Townsend  R, Hagerty D, Linsley PS, Peach RJ. Rational development of LEA29Y (belatacept), 
a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2005; 5(3):443-53. PubMed [journal] PMID: 15707398

35.   Adams AB, Shirasugi N, Jones TR, Durham MM, Strobert EA, Cowan S, Rees P, Hendrix R, Price K, Kenyon NS, Hagerty D, Townsend R, Hollenbaugh D, Pearson TC, Larsen CP. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. Journal of immunology (Baltimore, Md.: 1950). 2005; 174(1):542-50. PubMed [journal] PMID: 15611281

36.   Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wang L, Coyle AJ, Larsen CP, Shapiro AM. Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. American journal of transplantation : official journal of the American  Society of Transplantation and the American Society of Transplant Surgeons. 2004; 4(4):526-36. PubMed [journal] PMID: 15023144

37.   Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003; 102(13):4582-93. PubMed [journal] PMID:  12933586

38.   Jones TR, Shirasugi N, Adams AB, Pearson TC, Larsen CP. Intravital microscopy identifies selectins that regulate T cell traffic into allografts. The Journal of clinical investigation. 2003; 112(11):1714-23. PubMed [journal] PMID: 14660747, PMCID: PMC281648

39.   Jones TR, Adams AB, Shirasugi NJ, Bingaman AW, Durham MM, Pearson TC, Larsen CP.  Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2003; 3(12):1520-30. PubMed [journal] PMID: 14629282

40.   Adams AB, Pearson TC, Larsen CP. Heterologous immunity: an overlooked barrier to tolerance. Immunological reviews. 2003; 196:147-60. PubMed [journal] PMID: 14617203

41.   Guo Z, Wang J, Dong Y, Adams AB, Shirasugi N, Kim O, Hart J, Newton-West M, Pearson TC, Larsen CP, Newell KA. Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2003; 3(9):1091-8. PubMed [journal] PMID: 12919088

42.   Adams AB, Shirasugi N, Jones TR, Williams MA, Durham MM, Ha J, Dong Y, Guo Z,Newell KA, Pearson TC, Larsen CP. Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction. American
journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2003;
3(7):895-901. PubMed [journal] PMID: 12814483

43.   Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. Heterologous immunity provides a potent barrier to transplantation tolerance. The Journal of clinical investigation. 2003; 111(12):1887-95. PubMed [journal] PMID: 12813024, PMCID: PMC161424

44.   Wang J, Guo Z, Dong Y, Kim O, Hart J, Adams A, Larsen CP, Mittler RS, Newell KA.  Role of 4-1BB in allograft rejection mediated by CD8+ T cells. American journal of transplantation : official journal of the American Society of Transplantation  and the American Society of Transplant Surgeons. 2003; 3(5):543-51. PubMed [journal] PMID: 12752310

45.   Williams MA, Adams AB, Walsh MB, Shirasugi N, Onami TM, Pearson TC, Ahmed R, Larsen CP. Primary and secondary immunocompetence in mixed allogeneic chimeras. Journal of immunology (Baltimore, Md. : 1950). 2003; 170(5):2382-9. PubMed [journal] PMID: 12594261

46.   Williams MA, Onami TM, Adams AB, Durham MM, Pearson TC, Ahmed R, Larsen CP. Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. Journal of immunology (Baltimore, Md. : 1950). 2002; 169(10):5387-91. PubMed [journal] PMID: 12421910

47.   Shirasugi N, Adams AB, Durham MM, Lukacher AE, Xu H, Rees P, Cowan SR, Williams MA, Pearson TC, Larsen CP. Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens. Journal of immunology (Baltimore, Md. : 1950). 2002; 169(5):2677-84. PubMed [journal] PMID: 12193741

48.   Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller
EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable
mixed chimerism and tolerance induction after nonmyeloablative conditioning and
major histocompatibility complex-mismatched bone marrow transplantation. Blood.
2002; 99(5):1840-9. PubMed [journal] PMID: 11861303

49.   Costimulation Blockade and Tolerance Adams AB, Larsen CP, Pearson TC.
Current opinion in organ transplantation. 2002 March; 7(1):7-12. My Bibliography [journal] 

50.   Adams AB, Shirasugi N, Durham MM, Strobert E, Anderson D, Rees P, Cowan S, Xu H, 
Blinder Y, Cheung M, Hollenbaugh D, Kenyon NS, Pearson TC, Larsen CP. Calcineurin
inhibitor-free CD28 blockade-based protocol protects allogeneic islets in
nonhuman primates. Diabetes. 2002; 51(2):265-70. PubMed [journal] PMID: 11812731

51.   Jones TR, Ha J, Williams MA, Adams AB, Durham MM, Rees PA, Cowan SR, Pearson TC, 
Larsen CP. The role of the IL-2 pathway in costimulation blockade-resistant
rejection of allografts. Journal of immunology (Baltimore, Md. : 1950). 2002;
168(3):1123-30. PubMed [journal] PMID: 11801646

52.   Adams AB, Larsen CP, Pearson TC, Newell KA. The role of TNF receptor and TNF
superfamily molecules in organ transplantation. American journal of
transplantation : official journal of the American Society of Transplantation and
the American Society of Transplant Surgeons. 2002; 2(1):12-8. PubMed [journal]
PMID: 12095050

53.   Williams MA, Tan JT, Adams AB, Durham MM, Shirasugi N, Whitmire JK, Harrington
LE, Ahmed R, Pearson TC, Larsen CP. Characterization of virus-mediated inhibition
of mixed chimerism and allospecific tolerance. Journal of immunology (Baltimore, 
Md. : 1950). 2001; 167(9):4987-95. PubMed [journal] PMID: 11673506

54.   Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, 
Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP.
Costimulation blockade, busulfan, and bone marrow promote titratable
macrochimerism, induce transplantation tolerance, and correct genetic
hemoglobinopathies with minimal myelosuppression. Journal of immunology
(Baltimore, Md. : 1950). 2001; 167(2):1103-11. PubMed [journal] PMID: 11441122

55.   Adams AB, Pearson TC, Larsen CP. Conventional immunosuppression and
co-stimulation blockade. Philosophical transactions of the Royal Society of
London. Series B, Biological sciences. 2001; 356(1409):703-5. PubMed [journal]
PMID: 11375073, PMCID: PMC1088457

56.   Williams MA, Trambley J, Ha J, Adams AB, Durham MM, Rees P, Cowan SR, Pearson TC,
Larsen CP. Genetic characterization of strain differences in the ability to
mediate CD40/CD28-independent rejection of skin allografts. Journal of immunology
(Baltimore, Md. : 1950). 2000; 165(12):6849-57. PubMed [journal] PMID: 11120808

57.   Barney M, Call GB, McIlmoil CJ, Husein OF, Adams A, Balls AG, Oliveira GK, Miner
EC, Richards TA, Crawford BK, Heckmann RA, Bell JD, Judd AM. Stimulation by
interleukin-6 and inhibition by tumor necrosis factor of cortisol release from
bovine adrenal zona fasciculata cells through their receptors. Endocrine. 2000;
13(3):369-77. PubMed [journal] PMID: 11216650

 Durham MM, Bingaman AW, Adams AB, Ha J, Waitze SY, Pearson TC, Larsen CP. Cutting
edge: administration of anti-CD40 ligand and donor bone marrow leads to
hemopoietic chimerism and donor-specific tolerance without cytoreductive
conditioning. Journal of immunology (Baltimore, Md. : 1950). 2000; 165(1):1-4.
PubMed [journal] PMID: 10861026

Call GB, Husein OF, McIlmoil CJ, Adams A, Heckmann RA, Judd AM. Bovine adrenal
cells secrete interleukin-6 and tumor necrosis factor in vitro. General and
comparative endocrinology. 2000; 118(2):249-61. PubMed [journal] PMID: 10890565

 Judd AM, Call GB, Barney M, McIlmoil CJ, Balls AG, Adams A, Oliveira GK. Possible
function of IL-6 and TNF as intraadrenal factors in the regulation of adrenal
steroid secretion. Annals of the New York Academy of Sciences. 2000; 917:628-37. 
PubMed [journal] PMID: 11268391

Gott JP, Thourani VH, Wright CE, Brown WM 3rd, Adams AB, Skardasis GM, McKinnon
WM, Battey PM, Guyton RA. Risk neutralization in cardiac operations: detection
and treatment of associated carotid disease. The Annals of thoracic surgery.
1999; 68(3):850-6; discussion 856-7. PubMed [journal] PMID: 10509973

Thourani VH, Feliciano DV, Cooper WA, Brady KM, Adams AB, Rozycki GS, Symbas PN. 
Penetrating cardiac trauma at an urban trauma center: a 22-year perspective. The American surgeon. 1999; 65(9):811-6; discussion 817-8. PubMed [journal] PMID: 10484082