To better understand where we are going, it's helpful to understand where our group came from. Chris Larsen and Tom Pearson built the Emory Transplant Center with a foundation in strong scientific investigation. Their seminal observations of the required costimulatory signals for alloreactivity (click here for article) launched numerous avenues of investigation and discovery, and culminated in the translation of a new strategy for transplant therapy - costimulatory blockade. Their leadership, then and now, in science, patient care, and continually improving processes push our lab and our group to do better and be better. More thorough perspectives on their journey and contributions are catalogued in open online publications here. The leadership team at our transplant center includes former trainees of the center, a testament to the excellence in training and the scientific experience. Furthermore, a number of faculty such as Dr. Ken Newell, Past president of the American Society of Transplantation, are involved in research and advisory roles. Dr. Mandy Ford, the current scientific Director of the Transplant Center and frequent collaborator has continued to make key contributions and elucidate mechanisms by which costimulation blockade and transplant tolerance work. Her work has grown to fields of autoimmunity, tumor immunology and sepsis. The transplant center has a vibrant history of prominent investigators who continue to enhance academic medicine and transplantation. These strong foundations allow us to continue to push into new frontiers in transplantation, with the hope of improving patient health and happiness.